EGFR stands for Epidermal Growth Factor Receptor, a protein found on the surface of certain cells that plays a role in cell growth and division. Also known as ErbB1 or HER1, it belongs to a family of receptors called the ErbB family.
EGFR is activated by binding to specific ligands such as epidermal growth factor (EGF) or transforming growth factor alpha (TGF-alpha), which triggers a signaling cascade leading to cell proliferation, differentiation, and survival.
However, abnormal activation of EGFR can lead to uncontrolled cell growth and division, a hallmark of cancer.
EGFR is a target for cancer treatment, and several drugs that inhibit its activity, such as gefitinib and erlotinib, have been developed. These drugs are used to treat a variety of cancers, including non-small cell lung cancer and pancreatic cancer, among others.
EGFR value, is a parameter used to measure kidney function. It measures how effectively the kidneys clear waste products from the body.
It is especially monitored in people with chronic kidney disease (CKD). EGFR value, can vary depending on a person's age, gender, race, and body weight. Generally, a value above 90 ml/minute/1.73 m² is considered normal.
Doctors evaluate how good or bad kidney function is based on the EGFR value. A low EGFR value, It may indicate that the kidneys are not functioning adequately and that kidney disease is progressing. Doctors take this value into account when planning treatment.
